DUPUYTREN'S DISEASE
Anatomy
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Palmar fascia
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Superficial palmar fascia lies deep to subcutaneous tissue​
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Proximally starts at termination of palmaris longus tendon (when present)​
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Extends distally as 4 central bands of fascia toward each finger (no centra band for thumb)
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At distal palmar crease, central bands are bridged transversely by superficial transverse palmar ligament
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Central band branches into 3 directions:
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Superficial (vertical) fibres​
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Intermediate (longitudinal) fibres
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Deep (transverse) fibres - Usually spared from contractures
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Natatory ligaments​
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Subdermal fascial layer bordering the periphery of the web spaces from thumb to little finger​
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Known as distal first web space ligament in the 1st web space
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In continuity with Grayson ligament
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Cleland ligaments (dorsal to neurovascular bundles)​
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Pathology
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Dupuytren's fascia has higher proportion of type III collagen than normal fascia
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3 stages:
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Nodule formation
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Cord formation without contracture
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Mature cords with finger contractures
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Terminology:​
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Bands are normal fascia​
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Cords are pathological​
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Demographics
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Highest prevalence in older Caucasian men
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Uncommon under 40 years old
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Positive family history is the strongest predictor of disease and associated with earlier age of onset and earlier age of first treatment
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No known aetiology
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Associated with (but not causative of):
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Hypercholoesterolaemia​
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Diabetes
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Tobacco smoking
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Excessive alcohol
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Epilepsy
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Antiepilectic medication
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Trauma
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Chronic heavy manual labour
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Clinical examination
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Early signs:
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Skin tightness​
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Contour changes
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Nodules
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Cords without contractures
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Prominence ofpalmar monticuli
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Dorsal Dupuytren nodules (Garrods pads pr knuckle pads)
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Dupuytren's contracture
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Passive extension deficit affecting MCPJ and PIPJ​
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Specific cords result in specific contractures​:
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MCPJ​ contracture - Pretendinous cord, pretendinous portion of spiral cord
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PIPJ contracture
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Spiral cord - Pretendinous band, spiral band, ​lateral digital sheet and Grayson's ligament
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Central cord - Continuation of the pretendinous fibres from the palm to the digit
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Lateral cord - Runs from natatory ligament to the lateral digital sheet
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Web space contracture​ - Natatory cord
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DIPJ contracture - Retrovascular cord
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Management
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Surgery will not cure disease
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General indications
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Loss of function or difficulty with hygiene​
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MCPJ contracture >30° or PIPJ contracture of any degree
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Rapidly progressive disease
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General cnontraindications​
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Mild MCPJ joint contracture <30°â€‹
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Nodules or cords without contracture
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Unrealistic patient expectations
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Collagenase Clostridium histolyticum injections​
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45%-65% achieve near-full extension
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Only 1 cord can be treated at a time
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Indications​
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Contracture due to a palpable, tensionable cord with adequate skin reserve​
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Contraindications
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Severe allergic reaction​
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Tight skin or scars preventing extension
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Recurrence in young patient
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Infection or healing wounds
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Safety unknown in pregnancy, breastfeeding, <18 years
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Technique​
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Performed over 2 consecutive days per hand​
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Under sterile conditions, the central substance of the chosen cord segment is injected at 3 closely spaced points and hand is wrapped in a soft immobilising bandage
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Manipulation is performed by surgon on postinjection days 1-4
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Static extension night time splint for 1 month, and active range-of-movement exercises during the day
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Needle fasciotomy
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Indications​
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Contracture due to a palpable, tensionable cord with adequate skin reserve​
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Contraindications​
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Unable to tolerate awake procedures
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Tight skin or scars preventing extension
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Recurrence in young patient
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Infection or healing wounds
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Technique​
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Local prep and field sterility​, local anaesthetic infiltration
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Small gauge hypodermic needle inserted, and while cord is maintained under tension, the needle tip is used to progressively sever fibres
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Procedure repeated for all chosen cords
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Light bandage, avoid strenous gripping for 1 week
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Fasciectomy
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Indications
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Failed minimally invasive treatment​
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Diffuse disease
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Concurrent treatment of secondary pathology
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Surgeon/patient preference
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Contraindications​
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Patients in whom a long operation, long recovery, postoperative therapy is not possible
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Skin tightness beyond what local flaps could be expected to correct
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Technique​​
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Segmental fasciectomy​
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Multiple short transverse or longitudinal C-shaped incisions​
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Nodules and cord segments excised
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Skin closed and soft bandage applied
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Regional fasciectomy​
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Longitudinal, longitudinal zigzag or transverse incisions​
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All visibly diseased tissue is removed​
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Dermofasciectomy
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Indications​
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Longitudinal skin shortage beyond capacity for local flaps to correct​
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Recurrect contracture with diffuse skin involvement or extensive scarring
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Devascularised skin during surgery
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Strong diathesis profile
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Contraindications​
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​Patients in whom a long operation, long recovery, postoperative therapy is not possible
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Patients in whom skin grafting is not advisable
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Technique​
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Wide extensile exposure in primary procedure, or limited exposure to planned areas for excision in recurrent cases​
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All zones of skin replacement excised
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Skin left to heal secondarily or closed with full thickness skin graft
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Complications
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Haematoma
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Injury to digital neurovascular structures
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Flap necrosis
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Dupuytren's flare response
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Graft failure
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Recurrence