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DUPUYTREN'S DISEASE

Anatomy

  • Palmar fascia

    • Superficial palmar fascia lies deep to subcutaneous tissue​

      • Proximally starts at termination of palmaris longus tendon (when present)​

      • Extends distally as 4 central bands of fascia toward each finger (no centra band for thumb)

      • At distal palmar crease, central bands are bridged transversely by superficial transverse palmar ligament

      • Central band branches into 3 directions:

        • Superficial (vertical) fibres​

        • Intermediate (longitudinal) fibres

        • Deep (transverse) fibres - Usually spared from contractures

      • Natatory ligaments​

        • Subdermal fascial layer bordering the periphery of the web spaces from thumb to little finger​

        • Known as distal first web space ligament in the 1st web space

        • In continuity with Grayson ligament

      • Cleland ligaments (dorsal to neurovascular bundles)​

Anatomy

Pathology

  • Dupuytren's fascia has higher proportion of type III collagen than normal fascia

  • 3 stages:

    • Nodule formation

    • Cord formation without contracture

    • Mature cords with finger contractures 

  • Terminology:​

    • Bands are normal fascia​

    • Cords are pathological​

Pathology

Demographics

  • Highest prevalence in older Caucasian men

  • Uncommon under 40 years old

  • Positive family history is the strongest predictor of disease and associated with earlier age of onset and earlier age of first treatment

  • No known aetiology

  • Associated with (but not causative of):

    • Hypercholoesterolaemia​

    • Diabetes

    • Tobacco smoking

    • Excessive alcohol

    • Epilepsy

    • Antiepilectic medication

    • Trauma

    • Chronic heavy manual labour

Demographics

Clinical examination

  • Early signs:

    • Skin tightness​

    • Contour changes

    • Nodules

    • Cords without contractures

    • Prominence ofpalmar monticuli

    • Dorsal Dupuytren nodules (Garrods pads pr knuckle pads)

  • Dupuytren's contracture

    • Passive extension deficit affecting MCPJ and PIPJ​

  • Specific cords result in specific contractures​:

    • MCPJ​ contracture - Pretendinous cord, pretendinous portion of spiral cord

    • PIPJ contracture

      • Spiral cord - Pretendinous band, spiral band, ​lateral digital sheet and Grayson's ligament

      • Central cord - Continuation of the pretendinous fibres from the palm to the digit

      • Lateral cord - Runs from natatory ligament to the lateral digital sheet

    • Web space contracture​ - Natatory cord

    • DIPJ contracture - Retrovascular cord

Clinical examination

Management

  • Surgery will not cure disease

  • General indications

    • Loss of function or difficulty with hygiene​

    • MCPJ contracture >30° or PIPJ contracture of any degree

    • Rapidly progressive disease

  • General cnontraindications​

    • Mild MCPJ joint contracture <30°â€‹

    • Nodules or cords without contracture

    • Unrealistic patient expectations

  • Collagenase Clostridium histolyticum injections​

    • 45%-65% achieve near-full extension

    • Only 1 cord can be treated at a time

    • Indications​

      • Contracture due to a palpable, tensionable cord with adequate skin reserve​

    • Contraindications

      • Severe allergic reaction​

      • Tight skin or scars preventing extension

      • Recurrence in young patient

      • Infection or healing wounds

      • Safety unknown in pregnancy, breastfeeding, <18 years 

    • Technique​

      • Performed over 2 consecutive days per hand​

      • Under sterile conditions, the central substance of the chosen cord segment is injected at 3 closely spaced points and hand is wrapped in a soft immobilising bandage

      • Manipulation is performed by surgon on postinjection days 1-4

      • Static extension night time splint for 1 month, and active range-of-movement exercises during the day

  • Needle fasciotomy

    • Indications​

      • Contracture due to a palpable, tensionable cord with adequate skin reserve​

    • Contraindications​

      • Unable to tolerate awake procedures

      • Tight skin or scars preventing extension

      • Recurrence in young patient

      • Infection or healing wounds

    • Technique​

      • Local prep and field sterility​, local anaesthetic infiltration

      • Small gauge hypodermic needle inserted, and while cord is maintained under tension, the needle tip is used to progressively sever fibres

      • Procedure repeated for all chosen cords

      • Light bandage, avoid strenous gripping for 1 week

  • Fasciectomy

    • Indications

      • Failed minimally invasive treatment​

      • Diffuse disease

      • Concurrent treatment of secondary pathology

      • Surgeon/patient preference

    • Contraindications​

      • Patients in whom a long operation, long recovery, postoperative therapy is not possible

      • Skin tightness beyond what local flaps could be expected to correct

    • Technique​​

      • Segmental fasciectomy​

        • Multiple short transverse or longitudinal C-shaped incisions​

        • Nodules and cord segments excised

        • Skin closed and soft bandage applied

      • Regional fasciectomy​

        • Longitudinal, longitudinal zigzag or transverse incisions​

        • All visibly diseased tissue is removed​

  • Dermofasciectomy

    • Indications​

      • Longitudinal skin shortage beyond capacity for local flaps to correct​

      • Recurrect contracture with diffuse skin involvement or extensive scarring

      • Devascularised skin during surgery

      • Strong diathesis profile

    • Contraindications​

      • ​Patients in whom a long operation, long recovery, postoperative therapy is not possible

      • Patients in whom skin grafting is not advisable

    • Technique​

      • Wide extensile exposure in primary procedure, or limited exposure to planned areas for excision in recurrent cases​

      • All zones of skin replacement excised

      • Skin left to heal secondarily or closed with full thickness skin graft

Management

Complications

  • Haematoma

  • Injury to digital neurovascular structures

  • Flap necrosis

  • Dupuytren's flare response

  • Graft failure

  • Recurrence

Complications
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